Article
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
Diabetes - 1 Dec 1999
Frayling T M, Walker M, McCarthy M I, Evans J C, Allen L I, Lynn S, Ayres S, Millauer B, Turner C, Turner R C, Sampson M J, Hitman G A, Ellard S, Hattersley A T
Abstract excerpt
The transmission disequilibrium test with use of trios (an affected proband with both parents) is a robust method for assessing the role of gene variants in disease that avoids the problem of population stratification that may confound conventional case/control studies and allows the detection of parent-of-origin effects. Trios have played a major role in defining genes in a number of polygenic conditions,...
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