Article
Investigating parent of origin effects in studies of type 2 diabetes and obesity.
Current diabetes reviews - 1 Nov 2008
Rampersaud Evadnie, Mitchell Braxton D, Naj Adam C, Pollin Toni I
Abstract excerpt
The role of parent-of-origin effects (POE) in the etiology of complex diseases such as type 2 diabetes (T2DM) and obesity is currently of intense interest, but still largely unclear. POE are transmittable genetic effects whereby the expression of the phenotype in the offspring depends upon whether the transmission originated from the mother or father. In mammals, POE can be caused by genetic imprinting,...
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