Article
The analysis of parental origin of alleles may detect susceptibility loci for complex disorders.
Human heredity - 1 Jul 1999
Paterson A D, Naimark D M, Petronis A
Abstract excerpt
The phenomenon of genomic imprinting describes the differential behavior of genes depending on their parental origin, and has been demonstrated in a few rare genetic disorders. In complex diseases, parent-of-origin effects have not been systematically studied, although there may be heuristic value in such an approach. Data from a genome scan performed using 356 affected sibling pair families with type 1 diabetes...
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