Article
Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans.
Diabetes - 1 Mar 2000
Pani M A, Knapp M, Donner H, Braun J, Baur M P, Usadel K H, Badenhoop K
Abstract excerpt
Vitamin D has been shown to exert manifold immunomodulatory effects. Because type 1 diabetes is regarded to be immune-mediated and vitamin D prevents the development of diabetes in the NOD mouse, we investigated the role of the vitamin D receptor (VDR) gene as a candidate for type 1 diabetes susceptibility. A total of 152 Caucasian families with at least one affected offspring were genotyped for four VDR...
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