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Article

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

Journal of autoimmunity - 1 Jun 1996

Bennett S T, Wilson A J, Cucca F, Nerup J, Pociot F, McKinney P A, Barnett A H, Bain S C, Todd J A

Abstract excerpt

IDDM2-encoded predisposition to type 1 diabetes has recently been mapped to the minisatellite or variable number of tandem repeat (VNTR) locus upstream of the insulin and insulin-like growth factor II genes on human chromosome 11p15.5. In a UK case-control study (n = 228 sporadic diabetics; n = 441 healthy controls), we show here that the genotype homozygous for VNTR class I alleles is predisposing to disease (RR...

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Identifiers

PMID: 8816980
DOI: 10.1006/jaut.1996.0057

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IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.PMID 8816980Read ↗

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Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.Semantic proximity Read ↗

Human type 1 diabetes and the insulin gene: principles of mapping polygenes.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.Semantic proximity Read ↗

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.Semantic proximity Read ↗

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Semantic proximity Read ↗

Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.Semantic proximity Read ↗

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.Semantic proximity Read ↗

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.Semantic proximity Read ↗

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