Article
Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Diabetes - 1 Jan 2000
Huxtable S J, Saker P J, Haddad L, Walker M, Frayling T M, Levy J C, Hitman G A, O'Rahilly S, Hattersley A T, McCarthy M I
Abstract excerpt
Variation at the variable number tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated with several phenotypes, including type 1 diabetes, polycystic ovary syndrome, and birth weight. Case-control studies have suggested that class III VNTR alleles are also associated with type 2 diabetes, but results have been inconsistent and may reflect population stratification. To explore further the...
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