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Article

IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype.

The American journal of pathology - 1 Feb 2011

von der Thüsen Jan H, Borensztajn Keren S, Moimas Silvia, van Heiningen Sandra, Teeling Peter, van Berkel Theo J C, Biessen Erik A L

Abstract excerpt

Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) phenotype. To investigate this hypothesis, we studied the effects of the highly inflammatory milieu of the atheroscleroti...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Muscle, Smooth, Vascular

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Share to Plaque, Atherosclerotic

Share to Receptor, IGF Type 1

Source

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Identifiers

PMID: 21281823
DOI: 10.1016/j.ajpath.2010.10.007
PMCID: PMC3069834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21281823-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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