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Article

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes.

Cardiovascular research - 1 Jan 2017

Fujisawa Takeshi, Wang Keqing, Niu Xi-Lin, Egginton Stuart, Ahmad Shakil, Hewett Peter, Kontos Christopher D, Ahmed Asif

Abstract excerpt

AIMS: Atherosclerosis is a chronic inflammatory disease occurring within the artery wall. A crucial step in atherogenesis is the infiltration and retention of monocytes into the subendothelial space of large arteries induced by chemokines and growth factors. Angiopoietin-1 (Ang-1) regulates angiogenesis and reduces vascular permeability and has also been reported to promote monocyte migration in vitro. We...

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Identifiers

PMID: 28069704
DOI: 10.1093/cvr/cvw223
PMCID: PMC5220674

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Source receipt: pubmed, retrieved 7 Sept 2026.

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