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Article

ARL13B regulates Sonic hedgehog signaling from outside primary cilia.

eLife - 4 Mar 2020

Gigante Eduardo D, Taylor Megan R, Ivanova Anna A, Kahn Richard A, Caspary Tamara

Abstract excerpt

ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of ARL13B (V358A) and showed it retains all known biochemical function. We found that ARL13BV358A protein was expressed but could not be detected in cilia, even...

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Share to ADP-Ribosylation Factors
Share to Cilia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32129762
DOI: 10.7554/eLife.50434
PMCID: PMC7075693

Genes

ARL13B
ARL3
INPP5E

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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