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Article

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in <i>Caenorhabditis elegans</i>

15 Mar 2010

Abstract excerpt

The small ciliary G protein Arl13b is required for cilium biogenesis and sonic hedgehog signaling and is mutated in patients with Joubert syndrome (JS). In this study, using Caenorhabditis elegans and mammalian cell culture systems, we investigated the poorly understood ciliary and molecular basis of Arl13b function. First, we show that Arl13b/ARL-13 localization is frequently restricted to a proximal ciliary...

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PMID: 20231383
DOI: 10.1083/jcb.200908133

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