Article
Arl13b and the exocyst interact synergistically in ciliogenesis.
Molecular biology of the cell - 15 Jan 2016
Seixas Cecília, Choi Soo Young, Polgar Noemi, Umberger Nicole L, East Michael P, Zuo Xiaofeng, Moreiras Hugo, Ghossoub Rania, Benmerah Alexandre, Kahn Richard A, Fogelgren Ben, Caspary Tamara, Lipschutz Joshua H, Barral Duarte C
Abstract excerpt
Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation. Arl13b is highly enriched in cilia and is required for ciliogenesis in multiple organs. Nevertheless, the precise role of Arl13b remains elusive. Here we...
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