Article
Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.
The Journal of biological chemistry - 15 Jun 2018
Aboudehen Karam, Farahani Shayan, Kanchwala Mohammed, Chan Siu Chiu, Avdulov Svetlana, Mickelson Alan, Lee Dayeon, Gearhart Micah D, Patel Vishal, Xing Chao, Igarashi Peter
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease that is characterized by the accumulation of numerous fluid-filled cysts in the kidney. ADPKD is primarily caused by mutations in two genes, PKD1 and PKD2 Long noncoding RNAs (lncRNA), defined by a length >200 nucleotides and absence of a long ORF, have recently emerged as epigenetic regulators of development and disease; however,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.