Article

Discovery and Engineering of a Therapeutic Interfering Particle (TIP): a combination self-renewing antiviral

2019-10-30

Abstract excerpt

Population-level control of HIV-1 faces recognized challenges, including the evolution of viral resistance and adherence issues in resource-limited settings. It has long been proposed that viral deletion mutants that conditionally self-renew at the expense of the wild-type virus (i.e., Defective Interfering Particles, DIPs 1 ) could constitute a long-term intervention that circumvents adherence challenges and has...

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Literature Corpus work: 6823c173-2bb6-5f05-9d44-ede3848a3ac8
DOI: 10.1101/820456

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