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Article

HIV-1 resistance to neutralizing antibodies: Determination of antibody concentrations leading to escape mutant evolution.

Virus research - 15 Jun 2016

Magnus Carsten, Reh Lucia, Trkola Alexandra

Abstract excerpt

Broadly neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1) are considered vital components of novel therapeutics and blueprints for vaccine research. Yet escape to even the most potent of these antibodies is imminent in natural infection. Measures to define antibody efficacy and prevent mutant selection are thus urgently needed. Here, we derive a mathematical framework to predict the...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26494166
DOI: 10.1016/j.virusres.2015.10.009

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