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Article

Enhancement of Transcription by a Splicing-Competent Intron Is Dependent on Promoter Directionality.

PLoS genetics - 1 May 2016

Agarwal Neha, Ansari Athar

Abstract excerpt

Enhancement of transcription by a splicing-competent intron is an evolutionarily conserved feature among eukaryotes. The molecular mechanism underlying the phenomenon, however, is not entirely clear. Here we show that the intron is an important regulator of promoter directionality. Employing strand-specific transcription run-on (TRO) analysis, we show that the transcription of mRNA is favored over the upstream...

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Identifiers

PMID: 27152651
DOI: 10.1371/journal.pgen.1006047
PMCID: PMC4859611

Genes

TRO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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