Article
Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis.
Journal of clinical immunology - 1 Jul 2016
Blom Anna M, Corvillo Fernando, Magda Michal, Stasiłojć Grzegorz, Nozal Pilar, Pérez-Valdivia Miguel Ángel, Cabello-Chaves Virginia, Rodríguez de Córdoba Santiago, López-Trascasa Margarita, Okrój Marcin
Abstract excerpt
Autoantibodies termed C3-nephritic factor (C3NeF), which stabilize convertases of the alternative complement pathway, often stimulate autoinflammatory diseases. However, knowledge about analogous autoantibodies acting on the classical pathway (C4NeF) is limited to a few reports, which indicate association with kidney dysfunction, systemic lupus erythematous, and infections. C4NeF may appear independently from...
Topics
- Antigen-Antibody Complex
- Autoantibodies
- Blood Proteins
- Complement Activation
- Complement C3-C5 Convertases
- Complement C4b
- Complement Membrane Attack Complex
- Complement System Proteins
- DNA Mutational Analysis
- Female
- Genotype
- Glomerulonephritis, Membranoproliferative