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Article

Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Aug 2016

Alfonzo-Méndez Marco A, Castillo-Badillo Jean A, Romero-Ávila M Teresa, Rivera Richard, Chun Jerold, García-Sáinz J Adolfo

Abstract excerpt

Human α1D-adrenoceptors are G protein-coupled receptors that mediate adrenaline/noradrenaline actions. There is a growing interest in identifying regulatory domains in these receptors and determining how they function. In this work, we show that the absence of the human α1D-adrenoceptor carboxyl tail results in altered ERK (extracellular signal-regulated kinase) and p38 phosphorylation states. Amino...

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Share to Adrenergic alpha-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p38 Mitogen-Activated Protein Kinases

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Identifiers

PMID: 27146292
DOI: 10.1007/s00210-016-1254-2
PMCID: PMC6042655

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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