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Article

Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor.

British journal of pharmacology - 1 Jan 1999

Bastepe M, Ashby B

Abstract excerpt

1. The prostaglandin EP4 receptor, which couples to stimulation of adenylyl cyclase, undergoes rapid agonist-induced desensitization when expressed in CHO-K1 cells. 2. Truncation of the 488-amino acid receptor at residue 350 removes the carboxy-terminal domain and abolishes desensitization. 3. To further delineate residues involved in desensitization, the receptor was truncated at position 408, 383 or 369....

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Identifiers

PMID: 10051157
DOI: 10.1038/sj.bjp.0702291
PMCID: PMC1565795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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