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Article

Mutating the dileucine motif of the human beta(2)-adrenoceptor reduces the high initial rate of receptor phosphorylation by GRK without affecting postendocytic sorting.

European journal of pharmacology - 10 Jun 2010

Awwad Hibah O, Millman Ellen E, Alpizar-Foster Estrella, Moore Robert H, Knoll Brian J

Abstract excerpt

The internalization of beta(2)-adrenoceptors after agonist activation results in a desensitized and phosphorylated receptor that either resensitizes by recycling to the cell surface or becomes degraded by postendocytic sorting to lysosomes. The duration and physiological effects of agonists there...

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Identifiers

PMID: 20193676
DOI: 10.1016/j.ejphar.2010.02.033
PMCID: PMC3132186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20193676-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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