Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human beta1-adrenergic receptor is subject to constitutive and regulated N-terminal cleavage.

The Journal of biological chemistry - 10 Sept 2010

Hakalahti Anna E, Vierimaa Miia M, Lilja Minna K, Kumpula Esa-Pekka, Tuusa Jussi T, Petäjä-Repo Ulla E

Abstract excerpt

The beta(1)-adrenergic receptor (beta(1)AR) is the predominant betaAR in the heart, mediating the catecholamine-stimulated increase in cardiac rate and force of contraction. Regulation of this important G protein-coupled receptor is nevertheless poorly understood. We describe here the biosynthetic profile of the human beta(1)AR and reveal novel features relevant to its regulation using an inducible heterologous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Adrenergic beta-Agonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Glycosylation

Share to Isoproterenol

Share to Peptide Hydrolases

Share to Protein Kinase C

Share to Receptors, Adrenergic, beta-1

Source

Open in PubMed Open full text

Identifiers

PMID: 20587416
DOI: 10.1074/jbc.M110.149989
PMCID: PMC2937912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human beta1-adrenergic receptor is subject to constitutive and regulated N-terminal cleavage.PMID 20587416Read ↗

Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage.Semantic proximity Read ↗

Co- and posttranslational modification of the alpha(1B)-adrenergic receptor: effects on receptor expression and function.Semantic proximity Read ↗

Altered O-glycosylation of β1-adrenergic receptor N-terminal single-nucleotide variants modulates receptor processing and functional activity.Semantic proximity Read ↗

A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation.Semantic proximity Read ↗

N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization.Semantic proximity Read ↗

Importance of N-glycosylation positioning for cell-surface expression, targeting, affinity and quality control of the human AT1 receptor.Semantic proximity Read ↗

Constitutive activity in the angiotensin II type 1 receptor: discovery and applications.Semantic proximity Read ↗

Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.Semantic proximity Read ↗

A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface.Semantic proximity Read ↗

Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation.Semantic proximity Read ↗

Characterization and functional divergence of the alpha 1-adrenoceptor gene family: insights from rainbow trout (Oncorhynchus mykiss).Semantic proximity Read ↗

Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.