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Article

Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization.

European journal of pharmacology - 15 Feb 2002

Liang Mei, Eason Margaret G, Theiss Cheryl T, Liggett Stephen B

Abstract excerpt

The alpha2A-adrenoceptor undergoes desensitization in response to protein kinase C activation. Using mutagenesis and recombinant expression we sought to determine the specific sites within the receptor which are phosphorylated by protein kinase C and are responsible for this desensitization. Ser/Thr in the third intracellular loop were substituted with Ala to create mutant receptors T272A, S258A, S324A and S360A....

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PMID: 11864637
DOI: 10.1016/s0014-2999(02)01280-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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