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Article

Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease.

Neurobiology of aging - 1 Jun 2016

Rieckmann Anna, Van Dijk Koene R A, Sperling Reisa A, Johnson Keith A, Buckner Randy L, Hedden Trey

Abstract excerpt

Prior studies have identified white matter abnormalities in Alzheimer's disease (AD). Yet, cross-sectional studies in normal older individuals show little evidence for an association between markers of AD risk (APOE4 genotype and amyloid deposition), and white matter integrity. Here, 108 normal older adults (age, 66-87) with assessments of apolipoprotein e4 (APOE4) genotype and assessment of amyloid burden by...

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Identifiers

PMID: 27143434
DOI: 10.1016/j.neurobiolaging.2016.03.016
PMCID: PMC4857135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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