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Apolipoprotein E4 and brain white matter integrity in Alzheimer's disease: tract-based spatial statistics study under 3-Tesla MRI.

Neuro-degenerative diseases - 1 Jan 2012

Bagepally Bhavani Shankara, Halahalli Harsha N, John John P, Kota Lakshminarayan, Purushottam Meera, Mukherjee Odity, Sivakumar Palanimuthu Thangaraju, Bharath Srikala, Jain Sanjeev, Varghese Mathew

Abstract excerpt

INTRODUCTION: Apolipoprotein E4 (ApoE ε4) polymorphism is a known genetic risk factor for Alzheimer's disease (AD). OBJECTIVES: To evaluate the role of ApoE ε4 on white matter structural integrity in AD. METHODS: Subjects were 32 patients with probable AD (ApoE ε4-positive: n = 15) and 18 matched controls (ApoE ε4-positive: n = 6). All subjects were right-handed, evaluated using standard scales and genotyped at...

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PMID: 22269984
DOI: 10.1159/000334761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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