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Article

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles.

Arthritis research & therapy - 17 May 2012

Law Soi Cheng, Street Shayna, Yu Chien-Hsiung Alan, Capini Christelle, Ramnoruth Sakoontalla, Nel Hendrik J, van Gorp Eline, Hyde Claire, Lau Kim, Pahau Helen, Purcell Anthony W, Thomas Ranjeny

Abstract excerpt

INTRODUCTION: Anti-citrullinated peptide antibodies are found in rheumatoid arthritis (RA) patients with HLA-DRβ chains encoding the shared epitope (SE) sequence. Citrullination increases self-antigen immunogenicity, through increased binding affinity to SE-containing HLA-DR molecules. To characterise T-cell autoreactivity towards citrullinated self-epitopes, we profiled responses of SE+ healthy controls and RA...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to CD4-Positive T-Lymphocytes

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Share to HLA-DRB1 Chains

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Source

Open in PubMed Open full text

Identifiers

PMID: 22594821
DOI: 10.1186/ar3848
PMCID: PMC3446499

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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