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Substitution of Glutamic Acid at Position 71 of DRβ1*04:01 and Collagen-Specific Tolerance Without Alloreactivity.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2025

Jha Vibha, Freed Brian M, Sunderhaus Elizabeth R, Lee Jessica E, Prage Edward B, Miglani Manjula, Rosloniec Edward F, Matsuda Jennifer L, Coulombe Marilyne G, McKee Amy S, Roark Christina L

Abstract excerpt

OBJECTIVE: The DRB1 locus is strongly associated with both susceptibility and resistance to rheumatoid arthritis (RA). DRB1 alleles encoding the VKA or VRA epitope in positions 11, 71, and 74 confer the highest risk of developing RA, whereas the allele encoding VEA is protective. We therefore investigated the feasibility of creating antigen-specific tolerance without inducing alloreactivity by replacing lysine...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39609038
DOI: 10.1002/art.43067
PMCID: PMC12039470

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