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Article

A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2016

Anderson Kirsten M, Roark Christina L, Portas Mary, Aubrey Michael T, Rosloniec Edward F, Freed Brian M

Abstract excerpt

OBJECTIVE: The shared epitope hypothesis posits that amino acids QR/KRAA in positions 70-74 of the DRΒ1 chain are responsible for rheumatoid arthritis susceptibility. However, even DRB1*04 alleles containing the shared epitope vary greatly with respect to degrees of susceptibility. This study was undertaken to conduct a molecular examination of the shared epitope hypothesis by measuring binding of arthritogenic...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes

Share to Genetic Predisposition to Disease

Share to HLA-DRB1 Chains

Share to Peptides

Source

Identifiers

PMID: 26866513
DOI: 10.1002/art.39636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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