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Article

Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes.

Infection and immunity - 1 Jul 2016

Zhu Luchang, Olsen Randall J, Horstmann Nicola, Shelburne Samuel A, Fan Jia, Hu Ye, Musser James M

Abstract excerpt

Variable-number tandem-repeat (VNTR) polymorphisms are ubiquitous in bacteria. However, only a small fraction of them has been functionally studied. Here, we report an intergenic VNTR polymorphism that confers an altered level of toxin production and increased virulence in Streptococcus pyogenes The nature of the polymorphism is a one-unit deletion in a three-tandem-repeat locus upstream of the rocA gene encoding...

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Identifiers

PMID: 27141081
DOI: 10.1128/IAI.00258-16
PMCID: PMC4936349

Genes

SPN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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