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Article

Regulatory rewiring confers serotype-specific hyper-virulence in the human pathogen group A Streptococcus.

Molecular microbiology - 1 Oct 2015

Miller Eric W, Danger Jessica L, Ramalinga Anupama B, Horstmann Nicola, Shelburne Samuel A, Sumby Paul

Abstract excerpt

Phenotypic heterogeneity is commonly observed between isolates of a given pathogen. Epidemiological analyses have identified that some serotypes of the group A Streptococcus (GAS) are non-randomly associated with particular disease manifestations. Here, we present evidence that a contributing factor to the association of serotype M3 GAS isolates with severe invasive infections is the presence of a null mutant...

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Identifiers

PMID: 26192205
DOI: 10.1111/mmi.13136
PMCID: PMC4675629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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