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Article

Single Amino Acid Replacements in RocA Disrupt Protein-Protein Interactions To Alter the Molecular Pathogenesis of Group A Streptococcus.

Infection and immunity - 19 Oct 2020

Bernard Paul E, Duarte Amey, Bogdanov Mikhail, Musser James M, Olsen Randall J

Abstract excerpt

Group A Streptococcus (GAS) is a human-specific pathogen and major cause of disease worldwide. The molecular pathogenesis of GAS, like many pathogens, is dependent on the coordinated expression of genes encoding different virulence factors. The control of virulence regulator/sensor (CovRS) two-component system is a major virulence regulator of GAS that has been extensively studied. More recent investigations have...

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PMID: 32817331
DOI: 10.1128/IAI.00386-20
PMCID: PMC7573446

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