Article
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2010
Olsen Randall J, Sitkiewicz Izabela, Ayeras Ara A, Gonulal Vedia E, Cantu Concepcion, Beres Stephen B, Green Nicole M, Lei Benfang, Humbird Tammy, Greaver Jamieson, Chang Ellen, Ragasa Willie P, Montgomery Charles A, Cartwright Joiner, McGeer Allison, Low Donald E, Whitney Adeline R, Cagle Philip T, Blasdel Terry L, DeLeo Frank R, Musser James M
Abstract excerpt
Single-nucleotide changes are the most common cause of natural genetic variation among members of the same species, but there is remarkably little information bearing on how they alter bacterial virulence. We recently discovered a single-nucleotide mutation in the group A Streptococcus genome that is epidemiologically associated with decreased human necrotizing fasciitis ("flesh-eating disease"). Working from...
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