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The group A Streptococcus accessory protein RocA: regulatory activity, interacting partners and influence on disease potential

29 Oct 2019

Abstract excerpt

The group A Streptococcus (GAS) causes diseases that range from mild (e.g. pharyngitis) to severely invasive (e.g. necrotizing fasciitis). Strain- and serotype-specific differences influence the ability of isolates to cause individual diseases. At the center of this variability is the CovR/S two-component system and the accessory protein RocA. Through incompletely defined mechanisms, CovR/S and RocA repress the...

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PMID: 31660653
DOI: 10.1111/mmi.14410

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