Article

Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction

2024-11-05

Abstract excerpt

Streptococcus pyogenes ( S. pyogenes ) is a leading cause of infection-related mortality in humans globally. The characteristic cell wall-anchored Group A Carbohydrate (GAC) is expressed by all S. pyogenes strains and consists of a polyrhamnose backbone with alternating N -acetylglucosamine (GlcNAc) side chains, of which 25% are decorated with glycerol phosphate (GroP). The genes in the gacA-L cluster are crit...

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Literature Corpus work: ad2b3fdf-4709-58c6-95c3-de98c8ebc830
DOI: 10.1101/2024.11.04.621835

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