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Article

Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.

The EMBO journal - 2 Jul 2001

Formosa T, Eriksson P, Wittmeyer J, Ginn J, Yu Y, Stillman D J

Abstract excerpt

Yeast Spt16/Cdc68 and Pob3 form a heterodimer that acts in both DNA replication and transcription. This is supported by studies of new alleles of SPT16 described here. We show that Spt16-Pob3 enhances HO transcription through a mechanism that is affected by chromatin modification, since some of the defects caused by mutations can be suppressed by deleting the histone deacetylase Rpd3. While otherwise conserved...

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Share to Antigens, Nuclear
Share to High Mobility Group Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11432837
DOI: 10.1093/emboj/20.13.3506
PMCID: PMC125512

Genes

SPN
SSRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.PMID 11432837Read ↗

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