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Article

Two secured FACT recruitment mechanisms are essential for heterochromatin maintenance.

Cell reports - 17 Aug 2021

Takahata Shinya, Chida Saori, Ohnuma Aoi, Ando Motoyoshi, Asanuma Takahiro, Murakami Yota

Abstract excerpt

FACT (facilitate chromatin transcription) is involved in heterochromatic silencing, but its mechanisms and function remain unclear. We reveal that the Spt16 recruitment mechanism operates in two distinct ways in heterochromatin. First, Pob3 mediates Spt16 recruitment onto the heterochromatin through its Spt16 dimerization and tandem PH domains. Without Pob3, Spt16 recruitment is partially reduced, exhibiting a...

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PMID: 34407404
DOI: 10.1016/j.celrep.2021.109540

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