Article
Single nucleotide polymorphism coverage and inference of N-acetyltransferase-2 acetylator phenotypes in wordwide population groups.
Pharmacogenetics and genomics - 1 Aug 2016
Suarez-Kurtz Guilherme, Fuchshuber-Moraes Mateus, Struchiner Claudio J, Parra Esteban J
Abstract excerpt
OBJECTIVE: Several algorithms have been proposed to reduce the genotyping effort and cost, while retaining the accuracy of N-acetyltransferase-2 (NAT2) phenotype prediction. Data from the 1000 Genomes (1KG) project and an admixed cohort of Black Brazilians were used to assess the accuracy of NAT2 phenotype prediction using algorithms based on paired single nucleotide polymorphisms (SNPs) (rs1041983 and rs1801280)...
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