Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype.

doi:10.1097/FPC.0b013e3283493a23

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Article

Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype.

Pharmacogenetics and genomics - 1 Oct 2011

Selinski Silvia, Blaszkewicz Meinolf, Lehmann Marie-Louise, Ovsiannikov Daniel, Moormann Oliver, Guballa Christoph, Kress Alexander, Truss Michael C, Gerullis Holger, Otto Thomas, Barski Dimitri, Niegisch Günter, Albers Peter, Frees Sebastian, Brenner Walburgis, Thüroff Joachim W, Angeli-Greaves Miriam, Seidel Thilo, Roth Gerhard, Dietrich Holger, Ebbinghaus Rainer, Prager Hans M, Bolt Hermann M, Falkenstein Michael, Zimmermann Anna, Klein Torsten, Reckwitz Thomas, Roemer Hermann C, Löhlein Dietrich, Weistenhöfer Wobbeke, Schöps Wolfgang, Hassan Rizvi Syed Adibul, Aslam Muhammad, Bánfi Gergely, Romics Imre, Steffens Michael, Ekici Arif B, Winterpacht Andreas, Ickstadt Katja, Schwender Holger, Hengstler Jan G, Golka Klaus

Abstract excerpt

Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing of antituberculosis drugs and bladder cancer epidemiology. In this study we compared a recently published tagging single nucleotide polymorphism (SNP) (rs1495741) to the conventional 7-SNP genotype (G191A, C282T, T341C, C481T, G590A, A803G and G857A haplotype pairs) and systematically analysed if novel SNP combinations...

Topics

Acetylation
Arylamine N-Acetyltransferase
Caffeine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Case-Control Studies

Ethnicity

Female

Genotype

Genotyping Techniques

Haplotypes

Humans

Linkage Disequilibrium

Male

Phenotype

Polymorphism, Single Nucleotide

Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 21750470
DOI: 10.1097/FPC.0b013e3283493a23

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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