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Article

SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2006

Sabbagh Audrey, Darlu Pierre

Abstract excerpt

PURPOSE: Genetic polymorphisms in the N-acetyltransferase 2 gene determine the individual acetylator status, which influences both the toxicity and efficacy profile of acetylated drugs. Determination of an individual's acetylation phenotype prior to initiation of therapy, through DNA-based tests, should permit to improve therapy response and reduce adverse events. However, due to extensive linkage disequilibrium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16481889
DOI: 10.1097/01.gim.0000200951.54346.d6

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype.PMID 16481889Read ↗

Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data.Semantic proximity Read ↗

Improvements in algorithms for phenotype inference: the NAT2 example.Semantic proximity Read ↗

A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.Semantic proximity Read ↗

NAT2 sequence polymorphisms and acetylation profiles in Indians.Semantic proximity Read ↗

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.Semantic proximity Read ↗

N-acetyltransferase 2 genotyping: an accurate and feasible approach for simultaneous detection of the most common NAT2 alleles.Semantic proximity Read ↗

Study of NAT2 genetic polymorphism in West African subjects: example of an healthy non-smoker Senegalese population.Semantic proximity Read ↗

Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations.Semantic proximity Read ↗

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype.Semantic proximity Read ↗

Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype.Semantic proximity Read ↗

Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene.Semantic proximity Read ↗

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