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Article

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

Nature medicine - 1 Jun 2016

Souroullas George P, Jeck William R, Parker Joel S, Simon Jeremy M, Liu Jie-Yu, Paulk Joshiawa, Xiong Jessie, Clark Kelly S, Fedoriw Yuri, Qi Jun, Burd Christin E, Bradner James E, Sharpless Norman E

Abstract excerpt

B cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase (EZH2), but the carcinogenic role of these mutations is unclear. Here we describe a mouse model in which the most common somatic Ezh2 gain-of-function mutation (EZH2(Y646F) in human; Ezh2(Y641F) in mouse) is conditionally expressed. Expression of Ezh2(Y641F) in mouse B cells or melanocytes caused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27135738
DOI: 10.1038/nm.4092
PMCID: PMC4899144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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