A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

doi:10.1182/blood-2012-12-473439

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Article

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

Blood - 19 Jun 2014

Berg Tobias, Thoene Silvia, Yap Damian, Wee Tracee, Schoeler Nathalie, Rosten Patty, Lim Emilia, Bilenky Misha, Mungall Andrew J, Oellerich Thomas, Lee Sherry, Lai Courteney K, Umlandt Patricia, Salmi Anisa, Chang Harry, Yue Lisa, Lai David, Cheng S-W Grace, Morin Ryan D, Hirst Martin, Serve Hubert, Marra Marco A, Morin Gregg B, Gascoyne Randy D, Aparicio Samuel A, Humphries R Keith

Abstract excerpt

The histone methyltransferase EZH2 is frequently mutated in germinal center-derived diffuse large B-cell lymphoma and follicular lymphoma. To further characterize these EZH2 mutations in lymphomagenesis, we generated a mouse line where EZH2(Y641F) is expressed from a lymphocyte-specific promoter. Spleen cells isolated from the transgenic mice displayed a global increase in trimethylated H3K27, but the mice did...

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Identifiers

PMID: 24802772
DOI: 10.1182/blood-2012-12-473439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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