EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma.

doi:10.1016/j.jid.2020.02.042

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Article

EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma.

The Journal of investigative dermatology - 1 Dec 2020

Tiffen Jessamy, Gallagher Stuart J, Filipp Fabian, Gunatilake Dilini, Emran Abdullah Al, Cullinane Carleen, Dutton-Register Ken, Aoude Lauren, Hayward Nick, Chatterjee Aniruddha, Rodger Euan J, Eccles Michael R, Hersey Peter

Abstract excerpt

The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with DNA methylation and silencing of genes involved in tumor suppression. In this study, we used chromatin immunoprecipitation and sequencing to identify key suppressor genes that are silenced by histone methylation in constitutively active EZH2(Y641) mutant melanoma and assessed whether these regions were also sites of DNA...

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Cell Line, Tumor
Chromatin Immunoprecipitation Sequencing
DNA Methylation
Datasets as Topic
Down-Regulation
Drug Resistance, Neoplasm
Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation, Neoplastic

Gene Silencing

Humans

Immune Checkpoint Inhibitors

Interferon-alpha

Interferon-gamma

Melanoma

Mice

Source

Open in PubMed

Identifiers

PMID: 32360600
DOI: 10.1016/j.jid.2020.02.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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