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Article

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation.

Oncogene - 22 Jan 2015

Sahasrabuddhe A A, Chen X, Chung F, Velusamy T, Lim M S, Elenitoba-Johnson K S J

Abstract excerpt

EZH2 (enhancer of zeste homolog 2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2), which trimethylates histone H3 (H3K27) to mediate gene repression. Somatic mutations, overexpression and hyperactivation of EZH2 have been implicated in the pathogenesis of several form...

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PMID: 24469040
DOI: 10.1038/onc.2013.571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24469040-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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