Article
Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.
Biochemical and biophysical research communications - 5 Aug 2016
Toki Hideaki, Minowa Osamu, Inoue Maki, Motegi Hiromi, Karashima Yuko, Ikeda Ami, Kaneda Hideki, Sakuraba Yoshiyuki, Saiki Yuriko, Wakana Shigeharu, Suzuki Hiroshi, Gondo Yoichi, Shiroishi Toshihiko, Noda Tetsuo
Abstract excerpt
Dominant mutations in the Serca2 gene, which encodes sarco(endo)plasmic reticulum calcium-ATPase, predispose mice to gastrointestinal epithelial carcinoma [1-4] and humans to Darier disease (DD) [14-17]. In this study, we generated mice harboring N-ethyl-N-nitrosourea (ENU)-induced allelic mutations in Serca2: three missense mutations and one nonsense mutation. Mice harboring these Serca2 mutations developed...
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