Article
Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump.
The Journal of biological chemistry - 20 Jul 2001
Liu L H, Boivin G P, Prasad V, Periasamy M, Shull G E
Abstract excerpt
Mutations in the human ATP2A2 gene, encoding sarco(endo)plasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), cause Darier disease, an autosomal dominant skin disease characterized by multiple keratotic papules in the seborrheic regions of the body. Mice with a single functional Atp2a2 allele (the mouse homolog of ATP2A2) were shown previously to have reduced levels of SERCA2 in heart and mildly impaired cardiac...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.