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Article

SCCA2-like serpins mediate genetic predisposition to skin tumors.

Cancer research - 15 Apr 2003

Gariboldi Manuela, Peissel Bernard, Fabbri Alessandra, Saran Anna, Zaffaroni Daniela, Falvella F Stefania, Spinola Monica, Tanuma Jun-ichi, Pazzaglia Simonetta, Mancuso Maria Teresa, Maurichi Andrea, Bartoli Cesare, Cataltepe Sule, Silverman Gary A, Pilotti Silvana, Hayashizaki Yoshihide, Okazaki Yasushi, Dragani Tommaso A

Abstract excerpt

Reasons for early onset skin cancer are poorly understood. Microarray analysis revealed overexpression of the Scca2 gene in the 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-S mice, or line phenotypically selected for high susceptibility to two-stage skin carcinogenesis, as compared with 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-R mice, which is resistant. A human skin squamous cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12702576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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