Article
Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2004
Lee Daekee, Cross Sally H, Strunk Karen E, Morgan Joanne E, Bailey Candice L, Jackson Ian J, Threadgill David W
Abstract excerpt
Mice heterozygous for the N-ethyl-N-nitrosourea-induced Waved-5 (Wa5) mutation, isolated in a screen for dominant, visible mutations, exhibit a wavy coat similar to mice homozygous for the recessive Tgfa wa1 or Egfr wa2 alleles. In this study, we show that Wa5 is a new allele of Egfr (Egfr Wa5) containing a missense mutation within the coding region for the highly conserved DFG motif of the tyrosine kinase...
Topics
- Alkylating Agents
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Base Sequence
- Cricetinae
- DNA Mutational Analysis
- ErbB Receptors
- Ethylnitrosourea
- Genes, Dominant
- Genetic Complementation Test
- Genotype