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Article

A mouse model of human oral-esophageal cancer.

The Journal of clinical investigation - 1 Sept 2002

Opitz Oliver G, Harada Hideki, Suliman Yasir, Rhoades Ben, Sharpless Norman E, Kent Ralph, Kopelovich Levy, Nakagawa Hiroshi, Rustgi Anil K

Abstract excerpt

Squamous cancers of the oral cavity and esophagus are common worldwide, but no good genetically based animal model exists. A number of environmental factors as well as genetic alterations have been identified in these cancers, yet the specific combination of genetic events required for cancer progression remains unknown. The Epstein-Barr virus ED-L2 promoter (L2) can be used to target genes in a specific fashion...

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Identifiers

PMID: 12235107
DOI: 10.1172/JCI15324
PMCID: PMC151126

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