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Article

Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.

Journal of cell science - 1 Nov 2011

Wang Yin, Bruce Allen T, Tu Caixia, Ma Keli, Zeng Li, Zheng Pan, Liu Yang, Liu Yan

Abstract excerpt

Mutations in sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) underlie Darier disease (DD), a dominantly inherited skin disorder characterized by loss of keratinocyte adhesion (acantholysis) and abnormal keratinization (dyskeratosis) resulting in characteristic mucocutaneous abnormalities. However, the molecular pathogenic mechanism by which these changes influence keratinocyte adhesion and viability...

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Source

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Identifiers

PMID: 22045735
DOI: 10.1242/jcs.084053
PMCID: PMC3215571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.PMID 22045735Read ↗

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