Article
No evidence for association between polymorphisms in GRM3 and schizophrenia.
BMC psychiatry - 13 May 2005
Norton Nadine, Williams Hywel J, Dwyer Sarah, Ivanov Dobril, Preece Anna C, Gerrish Amy, Williams Nigel M, Yerassimou Pamela, Zammit Stanley, O'Donovan Michael C, Owen Michael J
Abstract excerpt
BACKGROUND: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. METHODS: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs...
Topics
- Adult
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Male
- Polymorphism, Single Nucleotide
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate