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Article

Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2008

Mössner Rainald, Schuhmacher Anna, Schulze-Rauschenbach Svenja, Kühn Kai-Uwe, Rujescu Dan, Rietschel Marcella, Zobel Astrid, Franke Petra, Wölwer Wolfgang, Gaebel Wolfgang, Häfner Heinz, Wagner Michael, Maier Wolfgang

Abstract excerpt

In recent years, evidence has been accumulating indicating a major role of glutamate in the pathogenesis and pathophysiology of schizophrenia. Of particular importance in this regard are the metabotropic glutamate receptors (GRM). Thus, a recently published trial of the amino acid analogue LY2140023, which exerts its effects through the activation of the glutamate receptors GRM3/GRM2, showed an improvement of...

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Source

Identifiers

PMID: 18614340
DOI: 10.1016/j.euroneuro.2008.05.007

Genes

GRM3
GRM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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