Article
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2004
Egan Michael F, Straub Richard E, Goldberg Terry E, Yakub Imtiaz, Callicott Joseph H, Hariri Ahmad R, Mattay Venkata S, Bertolino Alessandro, Hyde Thomas M, Shannon-Weickert Cynthia, Akil Mayada, Crook Jeremy, Vakkalanka Radha Krishna, Balkissoon Rishi, Gibbs Richard A, Kleinman Joel E, Weinberger Daniel R
Abstract excerpt
GRM3, a metabotropic glutamate receptor-modulating synaptic glutamate, is a promising schizophrenia candidate gene. In a family-based association study, a common GRM3 haplotype was strongly associated with schizophrenia (P = 0.0001). Within this haplotype, the A allele of single-nucleotide polymorphism (SNP) 4 (hCV11245618) in intron 2 was slightly overtransmitted to probands (P = 0.02). We studied the effects of...
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